The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling

Cells. 2019 May 24;8(5):502. doi: 10.3390/cells8050502.

Abstract

Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated. The major pathway transducers Yap and Taz require cofactors to impart transcriptional control over target genes. Research into Yap/Taz-mediated epigenetic modifications has revealed their association with chromatin-remodeling complex proteins as a means of altering chromatin structure, therefore affecting accessibility and activity of target genes. Specifically, Yap/Taz have been found to associate with factors of the GAGA, Ncoa6, Mediator, Switch/sucrose nonfermentable (SWI/SNF), and Nucleosome Remodeling and Deacetylase (NuRD) chromatin-remodeling complexes to alter the accessibility of target genes. This review highlights the different mechanisms by which Yap/Taz collaborate with other factors to modify DNA packing at specific loci to either activate or repress target gene transcription.

Keywords: Hippo pathway; chromatin; epigenetic; transcription.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Cycle Proteins / metabolism
  • Chromatin Assembly and Disassembly / physiology*
  • DNA-Binding Proteins / metabolism
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism
  • Genes, Switch / physiology
  • Hippo Signaling Pathway
  • Histone Methyltransferases / metabolism
  • Humans
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism
  • Nuclear Proteins / metabolism
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism*
  • Transcriptional Coactivator with PDZ-Binding Motif Proteins
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • BANF1 protein, human
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Nuclear Proteins
  • Trans-Activators
  • Transcription Factors
  • Transcriptional Coactivator with PDZ-Binding Motif Proteins
  • Trl protein, Drosophila
  • WWTR1 protein, human
  • YAP-Signaling Proteins
  • YAP1 protein, human
  • Yki protein, Drosophila
  • brm protein, Drosophila
  • Histone Methyltransferases
  • Protein Serine-Threonine Kinases
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex