Background Recent investigations have identified a faster time to publication for imaging studies with higher diagnostic test accuracy (DTA), but it is unknown whether such studies are more likely to be published. A higher probability of full-text publication for studies with higher DTA could have negative consequences on clinical decision making and patient care. Purpose To evaluate the proportion of imaging diagnostic accuracy studies presented as conference abstracts that reach full-text publication and to identify whether there is an association between diagnostic accuracy and full-text publication in peer-reviewed journals within 5 years after abstract submission. Materials and Methods Diagnostic accuracy research abstracts presented at the Radiological Society of North America (RSNA) Annual Meeting in 2011 and 2012 were evaluated between September 1, 2017, and January 11, 2018. Sensitivity and specificity from the abstracts were used to calculate the Youden index (sensitivity + specificity-1); additional abstract characteristics were extracted. To identify full-text publications within 5 years after abstract submission, PubMed and Google Scholar were searched, and authors were contacted. Logistic regression analysis was used to assess for associations between higher diagnostic accuracy and full-text publication. Results A total of 7970 abstracts were evaluated, and 405 were included. Of these, 288 (71%) reached full-text publication within 5 years after abstract submission. Logistic regression analysis accounting for several confounding variables failed to show an association between reported Youden index in the conference abstract and probability of full-text publication (odds ratio, 1.01; 95% confidence interval: 0.99, 1.02; P = .21). Conclusion More than a quarter of abstracts presented at the RSNA Annual Meeting do not reach full-text publication in peer-reviewed journals. The magnitude of reported diagnostic accuracy was not associated with full-text publication, which is consistent with results of diagnostic accuracy studies in other medical specialties. © RSNA, 2019 Online supplemental material is available for this article. See also the editorial by Fielding in this issue.