Characterization of teaghrelin-like compounds from tea cultivars

Nat Prod Res. 2021 Jan;35(1):57-62. doi: 10.1080/14786419.2019.1613398. Epub 2019 May 28.

Abstract

Teaghrelins, identified originally in Chin-shin oolong tea, are unique acylated flavonoid tetraglycosides and proposed to be potential oral analogues of ghrelin. In the present study, two new teaghrelin-like compounds were characterized from tea cultivars (TTES No. 12), and their chemical structures were established by the spectroscopic and spectrometric analysis. However, due to the different location of rhamnose, these two teaghrelin-like compounds may not show significant ghrelin receptor affinity.[Figure: see text].

Keywords: Oolong tea; acylated flavonoid tetraglycoside; ghrelin receptor affinity; spectroscopic and spectrometric analysis.

MeSH terms

  • Acylation
  • Camellia sinensis / chemistry*
  • Flavonoids / chemistry*
  • Flavonoids / metabolism
  • Ghrelin / chemistry
  • Ghrelin / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Docking Simulation
  • Molecular Structure
  • Plant Extracts / chemistry
  • Receptors, Ghrelin / metabolism
  • Spectrometry, Mass, Electrospray Ionization
  • Tea / chemistry

Substances

  • Flavonoids
  • Ghrelin
  • Plant Extracts
  • Receptors, Ghrelin
  • Tea