Variations in Irisin, Bone Mineral Density, Bone Mineral Content, and Body Composition After Laparoscopic Bariatric Procedures in Obese Adults

Chunting Lu; Zejian Li; Jing Yang; Lie Feng; Cunchuan Wang; Qiping Shi

doi:10.1016/j.jocd.2019.05.002

Variations in Irisin, Bone Mineral Density, Bone Mineral Content, and Body Composition After Laparoscopic Bariatric Procedures in Obese Adults

J Clin Densitom. 2020 Apr-Jun;23(2):244-253. doi: 10.1016/j.jocd.2019.05.002. Epub 2019 May 10.

Authors

Chunting Lu¹, Zejian Li², Jing Yang³, Lie Feng⁴, Cunchuan Wang⁵, Qiping Shi⁶

Affiliations

¹ Science and Education Office, The First Affiliated Hospital, Jinan University, Guangzhou, China.
² Medical Centre of Stomatology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
³ Department of Internal Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, China.
⁴ Department of Endocrinology, The First Affiliated Hospital, Jinan University, Guangzhou, China.
⁵ Department of General Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China. Electronic address: twcc@jnu.edu.cn.
⁶ Department of Endocrinology, The First Affiliated Hospital, Jinan University, Guangzhou, China. Electronic address: qiping.shi@qq.com.

PMID: 31133501
DOI: 10.1016/j.jocd.2019.05.002

Abstract

Introduction: This study was aimed to assess irisin levels in obesity (OB) and T2DM individuals and investigate the dynamic changes of irisin, bone mineral density (BMD), bone mineral content, and body composition in 19 OB patients after laparoscopic bariatric procedures, and also to evaluate the correlation of irisin, with BMD and body composition.

Methods: Forty-five OB, 20 T2DM, and 20 healthy adults had been recruited. Levels of irisin were measured in all subjects. Metabolic characteristics were obtained from OB and T2DM patients. Nineteen patients were randomly assigned to be received Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) procedure and to be completed 6-month follow-up. Irisin, BMD, bone mineral content, and body composition were measured at each visit.

Results: Significantly higher circulating irisin levels were measured in the OB group compared with T2DM and control groups. FINS, C-P, HOMA-IR, FBCI, HBCI, ALT, AST, and UA levels of OB were significantly higher than those of T2DM patients. While FBG and HbA1c of the OB were significantly lower than T2DM group. There were significant differences among circulating irisin, BMD, and body composition after laparoscopic bariatric surgery. Levels of irisin were decreased after operations including both LRYGB and LSG surgery compared with preoperation. At each time point (1, 3, and 6 months) of postoperation, there was no significant difference in percentage of total weight loss between LSG and LRYGB group. The positive correlation of irisin levels with total BMD, muscle, and fat masses were found during 6-month follow-up after surgery.

Conclusions: The levels of irisin were higher in OB patients. There were positive correlations of irisin levels with total BMD, muscle, and fat masses during 6-month follow-up after surgery. Irisin may be involved in the occurrence and development of obese and it is related to BMD and body composition. Both LRYGB and LSG operations could decrease the circulating levels of irisin.

Keywords: Body composition; Bone mineral density; Irisin; Laparoscopic bariatric procedures; Obesity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bariatric Surgery*
Body Composition*
Body Mass Index
Bone Density*
Calcification, Physiologic*
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / complications
Female
Fibronectins / blood*
Humans
Laparoscopy*
Male
Obesity, Morbid / blood
Obesity, Morbid / complications
Obesity, Morbid / physiopathology*
Obesity, Morbid / surgery*

Substances

FNDC5 protein, human
Fibronectins