Microglia and Neutrophils to the Rescue

Trends Immunol. 2019 Jul;40(7):555-556. doi: 10.1016/j.it.2019.05.005. Epub 2019 May 24.

Abstract

Invasive candidiasis is a medical condition that is challenging to treat. A recent study (Drummond et al.Nat. Immunol. 2019;20:559-570) reveals new insights into the role of microglia and neutrophils in limiting fungal dissemination to the mouse brain. Gaining knowledge into tissue-specific protection mechanisms may ensure improved prognosis and disease management against fungal infections.

Keywords: fungal infection; innate immunity; microglia; neutrophils.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Antifungal Agents
  • CARD Signaling Adaptor Proteins
  • Candidiasis*
  • Immunity, Innate
  • Mice
  • Microglia
  • Neutrophil Infiltration
  • Neutrophils*

Substances

  • Antifungal Agents
  • CARD Signaling Adaptor Proteins
  • Card9 protein, mouse