[Synthesis and pharmacologic activity of benzothiopyranopyrazole and benzothiopyranoisoxazole carboxamides]

Abstract

A series of carboxamides of benzotiopyranopyrazoles and benzothiiopyranoisoxazoles was synthesized starting from benzothiopyran-4-one-3-methylglyoxylates through two synthetic methods and tested for anti-inflammatory, analgesic and cardiovascular activity. Some of these compounds display pronounced antiarrhythmic activity.