LncRNA TP73-AS1 is upregulated in non-small cell lung cancer and predicts poor survival

Gene. 2019 Aug 20:710:98-102. doi: 10.1016/j.gene.2019.05.044. Epub 2019 May 23.

Abstract

The present study was carried out to investigate the role of lncRNA TP73-AS1 in non-small cell lung cancer (NSCLC). We found that TP73-AS1 was upregulated in tumor tissues than in non-tumor tissues of NSCLC patients, and high expression levels of TP73-AS1 predicted poor survival. MiR-21 was also upregulated in tumor tissues and positively correlated with TP73-AS1. TP73-AS1 overexpression led to miR-21 upregulation, while miR-21 overexpression failed to affect TP73-AS1. TP73-AS1 and miR-21 overexpression caused the accelerated invasion and migration of NSCLC cells. However, TP73-AS1 overexpression failed to affect cell proliferation. Therefore, TP73-AS1 may upregulate miR-21 to promote NSCLC cell migration and invasion.

Keywords: Non-small cell lung cancer; Survival; lncRNA TP73-AS1; miR-21.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Female
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Male
  • MicroRNAs / genetics*
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Prognosis
  • RNA, Long Noncoding / genetics*
  • Survival Analysis
  • Up-Regulation*

Substances

  • MIRN21 microRNA, human
  • MicroRNAs
  • RNA, Long Noncoding
  • long non-coding RNA KIAA0495, human