Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation

Leuk Res. 2019 Jul:82:11-14. doi: 10.1016/j.leukres.2019.05.003. Epub 2019 May 9.
No abstract available

Keywords: Calreticulin; JAK/STAT signaling; Myeloproliferative neoplasm; Receptor; Thrombopoietin.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calreticulin / genetics*
  • Calreticulin / metabolism
  • Carcinogenesis / genetics*
  • Carcinogenesis / metabolism
  • Carcinogenesis / pathology
  • Cell Line, Tumor
  • Cell Proliferation
  • Disease Models, Animal
  • Gene Expression Regulation, Neoplastic*
  • Genetic Vectors / chemistry
  • Genetic Vectors / metabolism
  • Hematologic Neoplasms / genetics*
  • Hematologic Neoplasms / metabolism
  • Hematologic Neoplasms / mortality
  • Hematologic Neoplasms / pathology
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Myeloproliferative Disorders / genetics*
  • Myeloproliferative Disorders / metabolism
  • Myeloproliferative Disorders / mortality
  • Myeloproliferative Disorders / pathology
  • Precursor Cells, B-Lymphoid / metabolism
  • Precursor Cells, B-Lymphoid / pathology
  • Precursor Cells, B-Lymphoid / transplantation
  • Receptors, Thrombopoietin / genetics*
  • Receptors, Thrombopoietin / metabolism
  • Retroviridae / genetics
  • Retroviridae / metabolism
  • Survival Analysis
  • Transduction, Genetic
  • Transgenes
  • Transplantation, Heterologous

Substances

  • CALR protein, human
  • Calreticulin
  • Receptors, Thrombopoietin
  • MPL protein, human