Role of heterogeneous nuclear ribonucleoprotein K in tumor development

J Cell Biochem. 2019 Sep;120(9):14296-14305. doi: 10.1002/jcb.28867. Epub 2019 May 24.

Abstract

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA/DNA special binding protein that participates in regulating the expression of related genes, transcription, RNA alternative splicing, translation, posttranslational modification, cell signal transduction, cell movement, interacts with ncRNAs, and induces angiogenesis. Moreover, several cellular functions forcefully indicated that hnRNP K participates in tumorigenesis. Numerous studies indicated hnRNP K is aberrantly elevated in multiple tumors. In addition, hnRNP K abnormal accumulation in cytoplasmic is also associated with poor prognosis. This suggests that hnRNP K may play a role in the development and progression of tumors. However, related studies demonstrated that hnRNP K acts as a tumor suppressor to suppress tumor formation. Therefore, this paper aims to explore the role of hnRNPK in tumors.

Keywords: AS; hnRNP K; ncRNAs; posttranslational modification; tumor; virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation, Neoplastic
  • Heterogeneous-Nuclear Ribonucleoprotein K / genetics*
  • Heterogeneous-Nuclear Ribonucleoprotein K / metabolism
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Protein Binding
  • RNA / genetics
  • RNA / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / metabolism

Substances

  • DNA-Binding Proteins
  • Heterogeneous-Nuclear Ribonucleoprotein K
  • RNA-Binding Proteins
  • Tumor Suppressor Proteins
  • HNRNPK protein, human
  • RNA