Personalized medicine-concepts, technologies, and applications in inflammatory skin diseases

APMIS. 2019 May;127(5):386-424. doi: 10.1111/apm.12934.

Abstract

The current state, tools, and applications of personalized medicine with special emphasis on inflammatory skin diseases like psoriasis and atopic dermatitis are discussed. Inflammatory pathways are outlined as well as potential targets for monoclonal antibodies and small-molecule inhibitors.

Keywords: Atopic dermatitis; endotypes; immunology; inflammatory skin diseases; personalized medicine; precision medicine; psoriasis; targeted therapy.

Publication types

  • Review

MeSH terms

  • Atmosphere Exposure Chambers
  • Biomarkers
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / etiology
  • Dermatitis, Atopic / genetics
  • Epigenomics
  • Humans
  • Pharmacogenomic Testing
  • Precision Medicine* / methods
  • Proteomics
  • Psoriasis / drug therapy*
  • Transcriptome
  • Whole Genome Sequencing

Substances

  • Biomarkers