Invasive Meningococcal Disease due to Nongroupable Neisseria meningitidis-Active Bacterial Core Surveillance Sites, 2011-2016

Lucy A McNamara; Caelin C Potts; Amy Blain; Nadav Topaz; Mirasol Apostol; Nisha B Alden; Susan Petit; Monica M Farley; Lee H Harrison; Lori Triden; Alison Muse; Tasha Poissant; Xin Wang; Jessica R MacNeil

doi:10.1093/ofid/ofz190

Invasive Meningococcal Disease due to Nongroupable Neisseria meningitidis-Active Bacterial Core Surveillance Sites, 2011-2016

Open Forum Infect Dis. 2019 Apr 15;6(5):ofz190. doi: 10.1093/ofid/ofz190. eCollection 2019 May.

Authors

Affiliations

¹ Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
² California Emerging Infections Program, Oakland, California.
³ Emerging Infections Program, Communicable Disease Branch, Colorado Disease Control and Environmental Epidemiology Division, Denver, Colorado.
⁴ Connecticut Department of Public Health Epidemiology Program, Hartford, Connecticut.
⁵ Emory University School of Medicine and the Atlanta VAMC, Atlanta, Georgia.
⁶ Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁷ Emerging Infections Unit, Acute Disease Investigations and Control Section, Minnesota Department of Health, St. Paul, Minnesota.
⁸ New York State Department of Health Emerging Infections Program, Albany, New York.
⁹ Oregon Health Authority, Portland, Oregon.
¹⁰ Office of the Director, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Abstract

We characterized 22 meningococcal disease cases due to nongroupable Neisseria meningitidis, a rare cause of invasive disease. Disease presentation and severity were similar to those for serogroupable meningococcal disease. However, 7 (32%) patients had complement deficiency or abnormal complement testing results, highlighting the importance of complement testing for nongroupable cases.

Keywords: Neisseria meningitidis; complement component deficiency; meningococcal disease; nongroupable.