Cytotoxic Tigliane Diterpenoids from Croton damayeshu

J Nat Prod. 2019 Jun 28;82(6):1550-1557. doi: 10.1021/acs.jnatprod.9b00042. Epub 2019 May 22.

Abstract

Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane diterpenoids, crodamoids A-J (1-10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against two human tumor cell lines, A549 and HL-60 (IC50: 0.9-2.4 μM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Croton / chemistry*
  • Croton / toxicity
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Diterpenes / toxicity
  • HL-60 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phorbols / chemistry
  • Phorbols / toxicity*
  • Plant Leaves / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Phorbols