Emerging role of HOX genes and their related long noncoding RNAs in lung cancer

Lianlian Li; Xiaoyu Zhang; Qian Liu; Haipeng Yin; Yutao Diao; Zhiyong Zhang; Yang Wang; Yan Gao; Xia Ren; Juan Li; Dayong Cui; Yanqin Lu; Hongyan Liu

doi:10.1016/j.critrevonc.2019.04.019

Emerging role of HOX genes and their related long noncoding RNAs in lung cancer

Crit Rev Oncol Hematol. 2019 Jul:139:1-6. doi: 10.1016/j.critrevonc.2019.04.019. Epub 2019 Apr 27.

Authors

Lianlian Li¹, Xiaoyu Zhang¹, Qian Liu², Haipeng Yin¹, Yutao Diao¹, Zhiyong Zhang¹, Yang Wang¹, Yan Gao¹, Xia Ren¹, Juan Li¹, Dayong Cui³, Yanqin Lu⁴, Hongyan Liu⁵

Affiliations

¹ Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, 250062, Shandong, China.
² Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, 250062, Shandong, China; School of Life Science, Ludong University, Yantai, 264025, Shandong, China.
³ School of Life Sciences, Qilu Normal University, Jinan, 250200, Shandong, China.
⁴ Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, 250062, Shandong, China.
⁵ Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, 250062, Shandong, China. Electronic address: hyliudycui@aliyun.com.

PMID: 31112877
DOI: 10.1016/j.critrevonc.2019.04.019

Abstract

The transcription factor homeobox (Hox) proteins are the master regulator for the embryonic development. Studies have identified new functions for HOX in the regulation of metabolism and other primary cellular processes in humans. Their dysregulation has been observed in a variety of cancers and accumulating evidence has revealed the crucial role of HOX in cancer progression, metastasis, and resistance to therapy. HOX-related long non-coding RNAs (lncRNAs) became the most attracting lncRNAs recently that play critical role in gene regulation and chromatin dynamics in cancers. In this review, we explore the roles of HOX and their related lncRNAs in lung cancer, indicating HOX genes as potential therapeutic targets in lung cancer.

Keywords: Cancer progression; Drug resistance; Dysregulation; Homeobox genes; Long non-coding RNA; Non-small cell lung cancer.

Publication types

Review

MeSH terms

Animals
Gene Expression Regulation, Neoplastic*
Genes, Homeobox*
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / pathology*
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding