Do BACE inhibitor failures in Alzheimer patients challenge the amyloid hypothesis of the disease?

Expert Rev Neurother. 2019 Jul;19(7):599-602. doi: 10.1080/14737175.2019.1621751. Epub 2019 May 27.

Authors

Francesco Panza¹, Madia Lozupone², Mark Watling³, Bruno Pietro Imbimbo³

Affiliations

¹ a Unit of Epidemiological Research on Aging , National Institute of Gastroenterology and Research Hospital IRCCS "S. De Bellis" Castellana Grotte , Castellana Grotte , Bari , Italy.
² b Department of Basic Medicine, Neurodegenerative Disease Unit , Neuroscience, and Sense Organs, University of Bari Aldo Moro , Bari , Italy.
³ c Department of Research and Development , Chiesi Farmaceutici , Parma , Italy.

PMID: 31112433
DOI: 10.1080/14737175.2019.1621751

No abstract available

Keywords: Alzheimer’s disease; BACE inhibitors; MCI; cognitive disorders; dementia; lifestyle.

Publication types

Editorial