Abstract
We have introduced a non-hormonal hyperglycemia treatment strategy by using an injectable glucose-responsive boronic acid- zwitterionic nanogel. The synthesized system, similar to an artificial liver, is capable of storing/releasing glucose at high/low blood glucose concentrations. In vivo performance revealed that the injection of the nanogels can effectively regulate blood glucose in type 1 diabetic rats for at least 6 hours.
MeSH terms
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Animals
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Betaine / analogs & derivatives*
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Betaine / chemical synthesis
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Betaine / chemistry
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Betaine / pharmacology
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Blood Glucose / metabolism*
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Boronic Acids* / chemical synthesis
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Boronic Acids* / chemistry
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Boronic Acids* / pharmacology
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Diabetes Mellitus, Experimental* / blood
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Diabetes Mellitus, Experimental* / drug therapy
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Diabetes Mellitus, Type 1* / blood
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Diabetes Mellitus, Type 1* / drug therapy
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Gels
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Hyperglycemia* / blood
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Hyperglycemia* / drug therapy
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Male
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Nanostructures* / chemistry
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Nanostructures* / therapeutic use
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Rats
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Rats, Sprague-Dawley
Substances
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Blood Glucose
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Boronic Acids
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Gels
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Betaine
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sulfobetaine