Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels - a non-hormonal strategy for the potential treatment of hyperglycemia

Nanoscale. 2019 May 30;11(21):10167-10171. doi: 10.1039/c9nr01687b.

Abstract

We have introduced a non-hormonal hyperglycemia treatment strategy by using an injectable glucose-responsive boronic acid- zwitterionic nanogel. The synthesized system, similar to an artificial liver, is capable of storing/releasing glucose at high/low blood glucose concentrations. In vivo performance revealed that the injection of the nanogels can effectively regulate blood glucose in type 1 diabetic rats for at least 6 hours.

MeSH terms

  • Animals
  • Betaine / analogs & derivatives*
  • Betaine / chemical synthesis
  • Betaine / chemistry
  • Betaine / pharmacology
  • Blood Glucose / metabolism*
  • Boronic Acids* / chemical synthesis
  • Boronic Acids* / chemistry
  • Boronic Acids* / pharmacology
  • Diabetes Mellitus, Experimental* / blood
  • Diabetes Mellitus, Experimental* / drug therapy
  • Diabetes Mellitus, Type 1* / blood
  • Diabetes Mellitus, Type 1* / drug therapy
  • Gels
  • Hyperglycemia* / blood
  • Hyperglycemia* / drug therapy
  • Male
  • Nanostructures* / chemistry
  • Nanostructures* / therapeutic use
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Blood Glucose
  • Boronic Acids
  • Gels
  • Betaine
  • sulfobetaine