Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery

Rie Wakabayashi; Hiroki Obayashi; Ryuichiro Hashimoto; Noriho Kamiya; Masahiro Goto

doi:10.1039/c9cc02473e

Complementary interaction with peptide amphiphiles guides size-controlled assembly of small molecules for intracellular delivery

Chem Commun (Camb). 2019 Jun 13;55(49):6997-7000. doi: 10.1039/c9cc02473e.

Authors

Rie Wakabayashi¹, Hiroki Obayashi, Ryuichiro Hashimoto, Noriho Kamiya, Masahiro Goto

Affiliation

¹ Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. rie_wakaba@mail.cstm.kyushu-u.ac.jp m-goto@mail.cstm.kyushu-u.ac.jp.

PMID: 31112157
DOI: 10.1039/c9cc02473e

Abstract

We introduced complementary interactions between peptide amphiphiles and a small fluorescence dye to develop a programmable multi-component supramolecular assembly, and intracellular delivery of the dye was controlled by the dimensions of the co-assembly, which was manipulated by the peptide design.

MeSH terms

Drug Delivery Systems*
Dynamic Light Scattering
Fluorescent Dyes / chemistry*
HeLa Cells
Humans
Peptides / chemical synthesis
Peptides / chemistry*
Small Molecule Libraries / chemistry*
Surface-Active Agents / chemical synthesis
Surface-Active Agents / chemistry*

Substances

Fluorescent Dyes
Peptides
Small Molecule Libraries
Surface-Active Agents