ARID5B gene polymorphisms and the risk of childhood acute lymphoblastic leukemia: a meta-analysis

Int J Hematol. 2019 Sep;110(3):272-284. doi: 10.1007/s12185-019-02658-2. Epub 2019 May 20.

Abstract

Genome-wide association studies have implicated several single-nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene in children with ALL; however, whether ARID5B variants (rs10821936, rs10994982, rs7089424) are associated with childhood ALL remains controversial. We performed this study to obtain more conclusive results. Eligible studies were searched in PubMed, Web of Science, and EMBASE. Odds ratios and 95% confidence intervals were calculated. A total of 26 studies were included. Analyses stratified by ethnicity revealed that three polymorphisms are significantly associated with the odds of childhood ALL in Caucasians, and rs10994982 and rs7089424 with the odds of childhood ALL in Asian populations. Furthermore, subtype analyses provided strong evidence that the three polymorphisms are highly associated with the risk of B-cell ALL. Our findings indicate that the ARID5B variants (rs10821936, rs10994982, rs7089424) are significantly associated with the risk of childhood ALL.

Keywords: ARID5B; Childhood leukemia; Meta-analysis.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Child
  • DNA-Binding Proteins / genetics*
  • Female
  • Genome-Wide Association Study
  • Humans
  • Male
  • Neoplasm Proteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Risk Factors
  • Transcription Factors / genetics*

Substances

  • ARID5B protein, human
  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Transcription Factors