Euglycemic diabetic ketoacidosis in association with dapagliflozin use after gastric sleeve surgery in a patient with type II diabetes mellitus

Iouri Banakh; Ross Kung; Sachin Gupta; Kati Matthiesson; Ravindranath Tiruvoipati

doi:10.1002/ccr3.2147

Euglycemic diabetic ketoacidosis in association with dapagliflozin use after gastric sleeve surgery in a patient with type II diabetes mellitus

Clin Case Rep. 2019 Apr 21;7(5):1087-1090. doi: 10.1002/ccr3.2147. eCollection 2019 May.

Authors

Iouri Banakh¹, Ross Kung², Sachin Gupta^{2

3}, Kati Matthiesson⁴, Ravindranath Tiruvoipati^{2

3}

Affiliations

¹ Pharmacy Department Frankston Hospital Frankston Victoria Australia.
² Department of Intensive Care Medicine Frankston Hospital Frankston Victoria Australia.
³ School of Public Health, Faculty of Medicine, Nursing and Health Sciences Monash University Frankston Victoria Australia.
⁴ Victorian Diabetes and Endocrine Network Malvern Victoria Australia.

Abstract

Sodium-glucose cotransporter 2 inhibitors (SGLT2Is) can be associated with euglycemic diabetic ketoacidosis (eDKA). Severe metabolic acidosis with extreme electrolyte abnormalities can occur with nonsignificant blood glucose elevations in SGLT2I-treated patients. Additional risk factors for eDKA include prolonged fasting, major illness, large weight loss, and reductions in insulin doses.

Keywords: diabetes; electrolyte correction; euglycemic diabetic ketoacidosis; intensive care; sodium–glucose cotransporter 2 inhibitor.

Publication types

Case Reports