The blaNDM-1-Carrying IncA/C2 Plasmid Underlies Structural Alterations and Cointegrate Formation In Vivo

Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00380-19. doi: 10.1128/AAC.00380-19. Print 2019 Aug.

Abstract

In 2012, a carbapenemase-producing Salmonella enterica serovar Corvallis isolate carrying a blaNDM-1 multiresistance IncA/C2 plasmid, apart from IncHI2 and ColE-like plasmids, was detected in a wild bird in Germany. In a recent broiler chicken infection study, we observed transfer of this blaNDM-1-carrying IncA/C2 plasmid to other Enterobacteriaceae Here, we focused on the stability of this plasmid and gained insight into the type and frequency of its structural alterations after an in vivo passage in a broiler chicken infection study.

Keywords: NDM-1 carbapenemases; Salmonella; broiler chicken infection study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chickens
  • Conjugation, Genetic
  • Plasmids / genetics*
  • Poultry Diseases / microbiology*
  • Salmonella Infections, Animal / microbiology*
  • Salmonella enterica / genetics*
  • Salmonella enterica / pathogenicity
  • Whole Genome Sequencing
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases
  • beta-lactamase NDM-1