Feasibility of multiparametric imaging with PET/MR in nasopharyngeal carcinoma: A pilot study

Abstract

Objective: The aim of this pilot study was to explore the integrated positron emission tomography and magnetic resonance imaging scanner (PET/MR) for biological characterization of nasopharyngeal carcinoma (NPC) and potential therapeutic applications of dose painting (DP).

Patients and methods: Twenty-one NPC patients with PET/MR were included in this study. Overlap of tumor volumes was analyzed on T2-weighted images (volume of interest, VOI_T2), diffusion-weighted magnetic resonance imaging (VOI_DWI) and ¹⁸F-fluorodeoxyglucose positron emission tomography (VOI_PET). The overlap percentages of low-metabolic sub-region (cluster 1) and high-metabolic sub-region (cluster 2) in VOI_PET and VOI_DWI were analyzed by cluster analysis.

Results: Both the VOI_DWI and VOI_PET were encompassed in the VOI_T2, respectively 99.6% and 97.5%. The median tumor overlap was 94.4% (VOI_DWI within VOI_PET). The median overlap of cluster 2 in VOI_PET and VOI_DWI was 43.61% (27.67-52.66%) and 21.86%(10.47-40.89%), respectively. The median overlap of cluster 1 in VOI_PET and VOI_DWI was 48.03% (23.91-63.15%) and 24.40% (7.44-51.44%), respectively. Separation between clusters appeared to be defined by a SUV value.

Conclusion: For NPC, the VOIs of DWI and FDG PET were not overlapped completely and the volume defined by cluster-analysis might be meaningful for DP.

Keywords: Diffusion-weighted imaging; FDG-PET; Nasopharyngeal carcinoma; PET/MR.