CCN1-Induced Cellular Senescence Promotes Heart Regeneration

Teng Feng; Jufeng Meng; Shan Kou; Zhen Jiang; Xinyan Huang; Zhengkai Lu; Huan Zhao; Lester F Lau; Bin Zhou; Hui Zhang

doi:10.1161/CIRCULATIONAHA.119.039530

CCN1-Induced Cellular Senescence Promotes Heart Regeneration

Circulation. 2019 May 21;139(21):2495-2498. doi: 10.1161/CIRCULATIONAHA.119.039530.

Authors

Teng Feng^{1

2}, Jufeng Meng¹, Shan Kou^{1

2}, Zhen Jiang^{1

2}, Xinyan Huang^{1

2}, Zhengkai Lu^{1

2}, Huan Zhao^{2

3}, Lester F Lau⁴, Bin Zhou^{1

2

3

5}, Hui Zhang¹

Affiliations

¹ School of Life Science and Technology, ShanghaiTech University, China (T.F., J.M., S.K., Z.J., X.H., Z.L., B.Z., H. Zhang).
² University of Chinese Academy of Sciences, Beijing (T.F., S.K., Z.J., X.H., Z.L., H. Zhao, B.Z.).
³ State Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (H. Zhao, B.Z.).
⁴ Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine (L.F.L.).
⁵ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China (B.Z.).

PMID: 31107624
DOI: 10.1161/CIRCULATIONAHA.119.039530

No abstract available

Keywords: CCN1 protein; cellular senescence; fibroblasts; myocardial infarction; regeneration.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aniline Compounds / pharmacology
Animals
Cell Adhesion Molecules / deficiency
Cell Adhesion Molecules / genetics
Cell Proliferation* / drug effects
Cellular Senescence* / drug effects
Cysteine-Rich Protein 61 / genetics
Cysteine-Rich Protein 61 / metabolism*
Disease Models, Animal
Fibroblasts / drug effects
Fibroblasts / metabolism*
Fibroblasts / pathology
Fibrosis
Heart Injuries / genetics
Heart Injuries / metabolism*
Heart Injuries / pathology
Heart Injuries / physiopathology
Mice, Knockout
Myocytes, Cardiac / drug effects
Myocytes, Cardiac / metabolism*
Myocytes, Cardiac / pathology
Paracrine Communication
Regeneration* / drug effects
Signal Transduction
Sulfonamides / pharmacology
Time Factors
Tumor Suppressor Protein p53 / deficiency
Tumor Suppressor Protein p53 / genetics

Substances

Aniline Compounds
CCN1 protein, mouse
Cell Adhesion Molecules
Cysteine-Rich Protein 61
Postn protein, mouse
Sulfonamides
Trp53 protein, mouse
Tumor Suppressor Protein p53
navitoclax