New Delhi Metallo-β-Lactamase 5-Producing Klebsiella pneumoniae Sequence Type 258, Southwest China, 2017

Emerg Infect Dis. 2019 Jun;25(6):1209-1213. doi: 10.3201/eid2506.181939.

Abstract

We isolated a New Delhi metallo-β-lactamase 5 (NDM-5)-producing Klebsiella pneumoniae sequence type (ST) 258 strain in southwest China during 2017. The blaNDM-5 gene was acquired by horizontal plasmid transfer from NDM-5-producing Escherichia coli. We identified genomic characteristics in ST258 strains that differed from those of global K. pneumoniae carbapenemase-producing strains.

Keywords: China; Klebsiella pneumoniae; NDM-5 gene; New Delhi metallo-β-lactamase 5; ST258; antimicrobial resistance; bacteria; carbapenem-resistant K. pneumoniae; horizontal transfer; molecular evolution; plasmid; sequence type 258.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • China / epidemiology
  • Gene Expression Regulation, Bacterial / physiology
  • Gene Expression Regulation, Enzymologic / physiology*
  • Genotype
  • Humans
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / classification*
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • beta-Lactamases