Abstract
We present the first Golgi-targeted small-molecular pH-sensitive fluorescent probe RSG, which allows an off-on fluorescence response to Golgi acidification with high sensitivity and specificity. RSG has been successfully used for real-time monitoring of Golgi pH changes induced by drug treatment at the cellular level, as well as by the LPS-mediated inflammation in vivo.
MeSH terms
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Animals
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Cell Line, Tumor
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Fluorescent Dyes / chemistry*
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Golgi Apparatus / chemistry*
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Golgi Apparatus / metabolism
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Humans
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Hydrogen-Ion Concentration
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Inflammation / diagnostic imaging
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Inflammation / etiology
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Lipopolysaccharides / toxicity
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Mice
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Microscopy, Fluorescence
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Optical Imaging
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Rhodamines / chemistry*
Substances
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Fluorescent Dyes
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Lipopolysaccharides
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Rhodamines
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rhodamine B