Abstract
Many tick-borne flaviviruses causes fatal encephalitis in humans and animals with severe sequelae. However, it remains unclear how viral replication and pathogenicity contribute to the neurologic manifestations. In this paper, I summarized the specific replication mechanism of tick-borne flaviviruses in neurons and their effect on the pathogenicity of neurological disease. Our findings of the unique virus-host interaction in central nerve system will improve further understanding of the molecular mechanisms of viral replication and the pathogenicity of neurotropic viruses.
MeSH terms
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Amino Acids
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Animals
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Antigens, Viral / metabolism
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Central Nervous System / virology*
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Disease Models, Animal
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Encephalitis, Viral / virology
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Flavivirus / genetics
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Flavivirus / immunology
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Flavivirus / pathogenicity*
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Flavivirus / physiology*
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Flavivirus Infections / virology*
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Host-Pathogen Interactions
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Humans
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Mice
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Neurites / virology
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Neurons / virology
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Rats
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Ticks / virology*
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Viral Nonstructural Proteins / chemistry
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Viral Nonstructural Proteins / physiology*
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Virus Replication*
Substances
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Amino Acids
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Antigens, Viral
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NS5 protein, flavivirus
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Viral Nonstructural Proteins