Cellular Mechanisms and Epigenetic Changes: Role of Nutrition in Livestock

Ahmed Elolimy; Mario Vailati-Riboni; Yusheng Liang; Juan J Loor

doi:10.1016/j.cvfa.2018.12.001

Cellular Mechanisms and Epigenetic Changes: Role of Nutrition in Livestock

Vet Clin North Am Food Anim Pract. 2019 Jul;35(2):249-263. doi: 10.1016/j.cvfa.2018.12.001.

Authors

Ahmed Elolimy¹, Mario Vailati-Riboni¹, Yusheng Liang¹, Juan J Loor²

Affiliations

¹ Department of Animal Sciences, Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA.
² Department of Animal Sciences, Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA. Electronic address: jloor@illinois.edu.

PMID: 31103179
DOI: 10.1016/j.cvfa.2018.12.001

Abstract

In the context of physiologic responses that determine the growth, development, and health status of livestock, the role of epigenetics and the underlying cellular mechanisms it affects remain to be fully elucidated. Although recent work has provided evidence that maternal dietary energy level, carbohydrate type, or intestinal supply of methyl donors can elicit molecular changes in tissues of the embryo, fetus, or neonate, there are few data linking epigenetics with biochemical and physiologic outcomes. Therefore, efforts linking the epigenome with physiologic and developmental outcomes offer exciting opportunities for discoveries that can impact efficiency of nutrient use and well-being of livestock.

Keywords: Embryo; Histones; Methylation; Placenta; Pregnancy; Tissue.

Publication types

Review

MeSH terms

Animals
Diet / veterinary*
Epigenesis, Genetic
Female
Livestock / genetics*
Livestock / metabolism*
Nutritional Status
Pregnancy