Effects of combining modern recovery techniques with neurotrophic medication and standard treatment in stroke patients

Sci Total Environ. 2019 Aug 20:679:80-87. doi: 10.1016/j.scitotenv.2019.05.070. Epub 2019 May 7.

Abstract

Stroke is the main cause of disability after age 65, leaving survivors with sequels that require care and recovery treatment lasting years. It is estimated that by the year 2030 this pathology will be leading cause of mortality. To determine the efficacy of Lokomat training combined with neurotrophic medication and balneo-physiotherapeutic treatment in rehabilitation of post-stroke patients, a prospective study of 3 parallel groups was conducted: Group I (n = 22) - Lokomat, balneo-physiotherapy, and Cerebrolysin; Group II (n = 18) - Lokomat associated with balneo-physiotherapy; and Group III (n = 30) - balneo-physiotherapy alone (Control group). Patients were evaluated physically, neurologically, and functionally, according to the evolution of their motor deficiency, spasticity, functional independence and health-related quality of life. Patient improvement is significantly better (p < 0.05) in the group with associated therapies, especially during the first 6 months. Evolution was significantly better in all groups at 12 months than initially (p < 0.05), for all studied parameters and with the best effects in Group I (the three therapies combined). Association of Lokomat training with neurotrophic factors and classic recovery techniques improves the rehabilitation process in stroke patients.

Keywords: Lokomat; Neurotrophic medication; Recovery; Rehabilitation; Stroke.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amino Acids / therapeutic use*
  • Balneology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuroprotective Agents / therapeutic use*
  • Physical Therapy Modalities*
  • Prospective Studies
  • Robotics*
  • Romania
  • Stroke / drug therapy
  • Stroke / therapy*

Substances

  • Amino Acids
  • Neuroprotective Agents
  • cerebrolysin