Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?

Abstract

Mitochondria have been considered for a long time only as the principal source of building blocks and energy upon aerobic conditions. Recently they emerged as key players in cell proliferation, invasion and resistance to therapy. The most aggressive tumors are able to evade the immune-surveillance. Alterations in the mitochondria metabolism either in cancer cells or in host immune system cells are involved in such tumor-induced immune-suppression. This review will focus on the main mitochondrial dysfunctions in tumor and immune cell populations determining immune-resistance, and on the therapies that may target mitochondrial metabolism and restore a powerful anti-tumor immune-activity.

Keywords: Immunogenic cell death; Mitochondrial danger-associated molecular patterns; Mitochondrial metabolism; Tumor-induced immune-escape; Tumor-induced immune-suppression.