Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

Sofie Lautrup; Guofeng Lou; Yahyah Aman; Hilde Nilsen; Jun Tao; Evandro F Fang

doi:10.1016/j.neuint.2019.104469

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

Neurochem Int. 2019 Oct:129:104469. doi: 10.1016/j.neuint.2019.104469. Epub 2019 May 15.

Authors

Sofie Lautrup¹, Guofeng Lou¹, Yahyah Aman¹, Hilde Nilsen¹, Jun Tao², Evandro F Fang³

Affiliations

¹ EpiGen, Akershus University Hospital and Department of Clinical Molecular Biology, University of Oslo, 1478, Lørenskog, Norway.
² Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. Electronic address: taojun@mail.sysu.edu.cn.
³ EpiGen, Akershus University Hospital and Department of Clinical Molecular Biology, University of Oslo, 1478, Lørenskog, Norway; Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. Electronic address: e.f.fang@medisin.uio.no.

PMID: 31100304
DOI: 10.1016/j.neuint.2019.104469

Abstract

In neurons, defective mitophagy results in accumulation of damaged mitochondria, and finally leading to various neurodegenerative diseases, including Alzheimer's disease (AD). However, how mitophagy is defective in AD as well as how defective mitophagy contributes to AD is not fully understood. We give commentary on recent progress of this topic, highlighting the importance of mitophagy not only in neurons, but also in microglia, in forestalling pathology and cognitive decline in different animal models of AD.

Keywords: Ageing; Autophagy; Inflammation; Microglia; Mitophagy; NAD(+).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / metabolism*
Alzheimer Disease / therapy
Animals
Autophagy / physiology*
Humans
Inflammation
Microglia / metabolism*
Mitochondria / metabolism*
Mitochondria / pathology
Mitophagy / physiology
Neurons / metabolism