Dually Cross-Linked Supramolecular Hydrogel as Surface Plasmon Resonance Sensor for Small Molecule Detection

Macromol Rapid Commun. 2019 Jul;40(14):e1900189. doi: 10.1002/marc.201900189. Epub 2019 May 17.

Abstract

Dually cross-linked supramolecular hydrogels (DCSH) are designed to show responsive properties while maintaining the gel structure by introducing two different kinds of cross-links. This is realized by utilizing a photo-cross-linker for permanent cross-linking and β-cyclodextrin (β-CD) and ferrocene (Fc) as host-guest recognition pair. The DCSH shows increased swelling in the presence of the small target molecule adamantane amine (Ada). Ada can break the non-covalent bonding between β-CD and Fc through competitive molecular guest interaction with β-CD. By using a combination of surface plasmon resonance and optical waveguide spectroscopy, it is possible to use this behavior to construct a reversible sensor for specific small molecule detection.

Keywords: dually cross-linked; sensors; small molecules; supramolecular hydrogels; surface plasmon resonance.

MeSH terms

  • Biosensing Techniques*
  • Ferrous Compounds / chemistry
  • Hydrogels / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Metallocenes / chemistry
  • Molecular Structure
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / isolation & purification*
  • Surface Plasmon Resonance
  • beta-Cyclodextrins / chemistry

Substances

  • Ferrous Compounds
  • Hydrogels
  • Metallocenes
  • Polymers
  • Small Molecule Libraries
  • beta-Cyclodextrins
  • Polyethylene Glycols
  • ferrocene