A person stays indoors for about 85%∼90% time of his lifetime, and the need for a comfortable indoor environment is getting higher; thus, the air-conditioning dependency becomes intense too. Nowadays, residents focus on both the comfortable living environment and indoor air quality. A closed environment will become hazardous because of carbon dioxide released during respiration and toxic organic solvent vapor released from interior decoration. In order to improve the indoor air quality (IAQ), we must allow outer fresh air into the indoor space and release the dirty air out. But while taking in fresh air, the heat and factory/vehicle exhaust are also introduced. Indoor CO2, HCHO, and VOCs and outer dirty gas threaten human health badly. To solve this problem, we bring up an innovative low-power-consuming full-outer-air-intake natural air-conditioning system that completely separates intake and exhaust air, which is a solution for cross-contamination and makes mass/energy exchange by means of air and water. Design airflow exceeds 300∼500 CFM, steam evaporation mass rate reaches 3.13∼3.88 kg/hr, and heat exchange capacity becomes 1,855∼2,300 kcal/hr. The sensible heat effectiveness is 71%∼112%, and EER exceeds 14.05∼17.42 kcal/W·h. In addition, the system under design can be of positive or negative pressure status according to the user's or work's requirement. It creates a comfortable and healthy living environment by supplying clean and fresh outer ambient air with low power consumption.