Inflammatory Basis of Pulmonary Arterial Hypertension: Implications for Perioperative and Critical Care Medicine

Neil M Goldenberg; Marlene Rabinovitch; Benjamin E Steinberg

doi:10.1097/ALN.0000000000002740

Inflammatory Basis of Pulmonary Arterial Hypertension: Implications for Perioperative and Critical Care Medicine

Anesthesiology. 2019 Oct;131(4):898-907. doi: 10.1097/ALN.0000000000002740.

Authors

Neil M Goldenberg¹, Marlene Rabinovitch, Benjamin E Steinberg

Affiliation

¹ From the Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada (N.M.G., B.E.S.) Sick Kids Research Institute, Program in Cell Biology (N.M.G.) Program in Neuroscience and Mental Health (B.E.S.), Toronto, Ontario, Canada Department of Pediatrics and Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California (M.R.).

Abstract

Patients with pulmonary arterial hypertension have exceptionally high perioperative risk. This review summarizes the clinical presentation and therapies for PAH, and highlights evidence for inflammation as a driver of disease pathogenesis and a therapeutic target.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Critical Care / methods*
Humans
Inflammation / complications*
Perioperative Care / methods*
Pulmonary Arterial Hypertension / complications*
Pulmonary Arterial Hypertension / surgery

Abstract

Publication types

MeSH terms

Grants and funding