Specific and Selective Bacteriophages in the Fight against Multidrug-resistant Acinetobacter baumannii

Virol Sin. 2019 Aug;34(4):347-357. doi: 10.1007/s12250-019-00125-0. Epub 2019 May 15.

Abstract

Acinetobacter baumannii causes serious infections especially in immunocompromised and/or hospitalized patients. Several A. baumannii strains are multidrug resistant and infect wounds, bones, and the respiratory tract. Current studies are focused on finding new effective agents against A. baumannii. Phage therapy is a promising means to fight this bacterium and many studies on procuring and applying new phages against A. baumannii are currently being conducted. As shown in animal models, phages against multidrug-resistant A. baumannii may control bacterial infections caused by this pathogen and may be a real hope to solve this dangerous health problem.

Keywords: Acinetobacter baumannii; Bacteriophages; Multidrug resistance (MDR); Phage therapy.

Publication types

  • Review

MeSH terms

  • Acinetobacter Infections / therapy*
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / virology
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Bacteriophages / isolation & purification*
  • Bacteriophages / physiology
  • Disease Models, Animal
  • Drug Resistance, Multiple, Bacterial*
  • Humans
  • Phage Therapy*

Substances

  • Anti-Bacterial Agents