Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes

J Diabetes Investig. 2019 Nov;10(6):1593-1594. doi: 10.1111/jdi.13063. Epub 2019 May 15.

Abstract

QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpeak-Tend/QT in a subgroup with Tpeak-Tend/QT?0.25 (median).

Publication types

  • Letter

MeSH terms

  • Benzhydryl Compounds / therapeutic use*
  • Diabetes Mellitus, Type 2 / complications*
  • Follow-Up Studies
  • Glucosides / therapeutic use*
  • Humans
  • Longitudinal Studies
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Sodium-Glucose Transporter 2 Inhibitors / therapeutic use*
  • Ventricular Dysfunction / drug therapy*
  • Ventricular Dysfunction / etiology
  • Ventricular Dysfunction / pathology

Substances

  • Benzhydryl Compounds
  • Glucosides
  • Sodium-Glucose Transporter 2 Inhibitors
  • dapagliflozin