Loss of monocyte metabolic plasticity in endotoxin tolerance: A model for understanding sepsis-induced immune paralysis?

J Leukoc Biol. 2019 Jul;106(1):7-9. doi: 10.1002/JLB.4CE0319-100R. Epub 2019 May 14.

Authors

David L Williams^{1

2}, Chuanfu Li^{1

2}, Edward R Sherwood^{2

3}

Affiliations

¹ Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA.
² Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, Tennessee, 37614, USA.
³ Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.

Abstract

Discussion on implications of the immune paralysis that occurs in many sepsis patients.

©2019 Society for Leukocyte Biology.

Publication types

Editorial
Research Support, N.I.H., Extramural
Comment

MeSH terms

Endotoxins
Humans
Immune Tolerance
Monocytes*
Respiratory Burst
Sepsis*

Substances

Endotoxins

Grants and funding