GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO2-coated porphyrin metal organic framework

Xue-Tao Tian; Pei-Pei Cao; Hui Zhang; Yu-Hao Li; Xue-Bo Yin

doi:10.1039/c9cc01957j

GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO₂-coated porphyrin metal organic framework

Chem Commun (Camb). 2019 May 28;55(44):6241-6244. doi: 10.1039/c9cc01957j.

Authors

Xue-Tao Tian¹, Pei-Pei Cao, Hui Zhang, Yu-Hao Li, Xue-Bo Yin

Affiliation

¹ State Key Laboratory of Medicinal Chemical, Biology and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, 300071, China. xbyin@nankai.edu.cn.

PMID: 31086880
DOI: 10.1039/c9cc01957j

Abstract

Glutathione (GSH) in tumors consumes 1O2 and seriously inhibits the PDT effect. MnO2-coated porphyrin metal-organic frameworks are developed to realize the oxidation of GSH by MnO2 for enhanced PDT, activated MR imaging, and controllable release of DOX as magnetic resonance imaging guided drug-PDT dual-therapy.

MeSH terms

Combined Modality Therapy
Glutathione / metabolism*
Magnetic Resonance Imaging / methods*
Manganese Compounds / chemistry*
Metal-Organic Frameworks / chemistry*
Oxides / chemistry*
Photochemotherapy / methods*
Porphyrins / chemistry*

Substances

Manganese Compounds
Metal-Organic Frameworks
Oxides
Porphyrins
manganese oxide
Glutathione