In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

Peter W Nagle; Marc-Jan van Goethem; Marco Kempers; Harry Kiewit; Antje Knopf; Johannes A Langendijk; Sytze Brandenburg; Peter van Luijk; Rob P Coppes

doi:10.1016/j.radonc.2019.04.028

In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

Radiother Oncol. 2019 Aug:137:125-129. doi: 10.1016/j.radonc.2019.04.028. Epub 2019 May 11.

Authors

Peter W Nagle¹, Marc-Jan van Goethem², Marco Kempers³, Harry Kiewit⁴, Antje Knopf⁵, Johannes A Langendijk⁵, Sytze Brandenburg⁴, Peter van Luijk⁶, Rob P Coppes⁷

Affiliations

¹ Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
² Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands; KVI Center for Advanced Radiation Technology, University of Groningen, The Netherlands.
³ Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands.
⁴ KVI Center for Advanced Radiation Technology, University of Groningen, The Netherlands.
⁵ Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
⁶ Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
⁷ Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands. Electronic address: r.p.coppes@umcg.nl.

PMID: 31085392
DOI: 10.1016/j.radonc.2019.04.028

Abstract

To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response.

Keywords: MRI; Normal tissue; Organoids; Protons; Tumor.

MeSH terms

A549 Cells
Adenocarcinoma of Lung / radiotherapy
Adenocarcinoma of Lung / therapy*
Animals
Female
HEK293 Cells
Humans
Magnetic Field Therapy / methods*
Magnetic Resonance Imaging / methods
Mice
Mice, Inbred C57BL
Proton Therapy / methods*
Salivary Glands / cytology
Salivary Glands / radiation effects*
Stem Cells / cytology
Stem Cells / radiation effects