PET/Computed Tomography in Chronic Lymphocytic Leukemia and Richter Transformation

Joanna M Rhodes; Anthony R Mato

doi:10.1016/j.cpet.2019.03.007

PET/Computed Tomography in Chronic Lymphocytic Leukemia and Richter Transformation

PET Clin. 2019 Jul;14(3):405-410. doi: 10.1016/j.cpet.2019.03.007. Epub 2019 Apr 12.

Authors

Joanna M Rhodes¹, Anthony R Mato²

Affiliations

¹ Division of Hematology and Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Joanna.rhodes@uphs.upenn.edu.
² CLL Program, Leukemia Service, Division of Hematological Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

PMID: 31084779
DOI: 10.1016/j.cpet.2019.03.007

Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the United States. In 1-10% of cases, it can undergo Richter's transformation (RT) to either diffuse large B cell lymphoma (DLBCL) or Hodgkin's lymphoma (HL). Diagnosis requires histologic confirmation by tissue biopsy. PET/CT has been studied to in several series to look at its predictive value for identifying RT in biopsies. in this review, we will discuss the role of PET/CT to identify RT in patients CLL and its utility in clinical practice.

Keywords: Accelerated CLL; B-cell receptor inhibitor; Chronic lymphocytic leukemia; Ibrutinib; PET/CT; Richter transformation; Venetoclax.

Publication types

Review

MeSH terms

Biopsy
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / diagnostic imaging*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
Positron Emission Tomography Computed Tomography / methods*