Updates on Bioengineered Alternative Tissues

John Miller; Jacob Wynes

doi:10.1016/j.cpm.2019.02.009

Updates on Bioengineered Alternative Tissues

Clin Podiatr Med Surg. 2019 Jul;36(3):413-424. doi: 10.1016/j.cpm.2019.02.009. Epub 2019 Apr 8.

Authors

John Miller¹, Jacob Wynes²

Affiliations

¹ Baltimore VA Health System, Rubin Institute for Advanced Orthopedics, 10 North Greene Street, Baltimore, MD 21201, USA.
² Department of Orthopaedics, UMMC Limb Preservation Clinic, University of Maryland, University of Maryland School of Medicine, 2200 Kernan Drive, Baltimore, MD 21207, USA. Electronic address: Jwynes@som.umaryland.edu.

PMID: 31079607
DOI: 10.1016/j.cpm.2019.02.009

Abstract

Over the past quarter century, the management of diabetic wounds and their sequelae has improved dramatically. One of the greatest areas of advancement includes the development of bioengineered alternative tissues that act as adjuncts to the deficits of chronic wounds and accelerate healing. The use of bioengineered alternative tissues will likely only continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new additional products continue to cut costs and improve wound healing expectations. This article reviews common and novel bioengineered alternative tissue products, identifying their unique composition, function, and current published outcome data.

Keywords: Bioengineered tissue; Chronic wounds; Diabetic foot ulcer; Wound healing.

Publication types

Review

MeSH terms

Allografts
Diabetic Foot / epidemiology
Diabetic Foot / therapy*
Heterografts
Humans
Skin, Artificial*
Tissue Engineering*
Wound Healing*