Epidemic threshold in pairwise models for clustered networks: closures and fast correlations

J Math Biol. 2019 Aug;79(3):823-860. doi: 10.1007/s00285-019-01380-1. Epub 2019 May 11.

Abstract

The epidemic threshold is probably the most studied quantity in the modelling of epidemics on networks. For a large class of networks and dynamics, it is well studied and understood. However, it is less so for clustered networks where theoretical results are mostly limited to idealised networks. In this paper we focus on a class of models known as pairwise models where, to our knowledge, no analytical result for the epidemic threshold exists. We show that by exploiting the presence of fast variables and using some standard techniques from perturbation theory we are able to obtain the epidemic threshold analytically. We validate this new threshold by comparing it to the threshold based on the numerical solution of the full system. The agreement is found to be excellent over a wide range of values of the clustering coefficient, transmission rate and average degree of the network. Interestingly, we find that the analytical form of the threshold depends on the choice of closure, highlighting the importance of model selection when dealing with real-world epidemics. Nevertheless, we expect that our method will extend to other systems in which fast variables are present.

Keywords: Clustering; Correlation; Epidemic; Fast variables; Network; Pairwise model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Communicable Diseases / pathology*
  • Computer Simulation*
  • Epidemics / prevention & control*
  • Humans
  • Models, Theoretical*