Role of regulatory T cells in Schistosoma-mediated protection against type 1 diabetes

Chun-Lian Tang; Yan-Ru Gao; Li-Xia Wang; Ya-Wen Zhu; Qun Pan; Rong-Hui Zhang; Ying Xiong

doi:10.1016/j.mce.2019.04.014

Role of regulatory T cells in Schistosoma-mediated protection against type 1 diabetes

Mol Cell Endocrinol. 2019 Jul 1:491:110434. doi: 10.1016/j.mce.2019.04.014. Epub 2019 May 9.

Authors

Chun-Lian Tang¹, Yan-Ru Gao², Li-Xia Wang¹, Ya-Wen Zhu¹, Qun Pan¹, Rong-Hui Zhang¹, Ying Xiong³

Affiliations

¹ Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430063, China.
² Medical Department, City College, Wuhan University of Science and Technology, Wuhan, 430083, China.
³ Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430063, China. Electronic address: xiongying_123@126.com.

PMID: 31078638
DOI: 10.1016/j.mce.2019.04.014

Abstract

The prevalence of T1D in developed societies is partly based on the hygiene hypothesis, that is, the loss of exposure to infectious agents accompanies the loss of immune stimuli shaping the immune system during development. Indeed, the components of parasites, such as Schistosoma, have been reported to ameliorate or prevent the development of T1D, which might be associated with immune cell activity especially that of regulatory T cells (Tregs). Schistosoma infection can lead to the expansion of Treg. Herein, we provide a comprehensive overview of the involvement of Tregs in the response against Schistosoma infection and the mechanism of Schistosoma-associated host protection against T1D.

Keywords: NOD mouse; Non-obese diabetes; Regulatory T cell; Schistosoma; Type 1 diabetes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Diabetes Mellitus, Type 1 / immunology*
Diabetes Mellitus, Type 1 / metabolism
Diabetes Mellitus, Type 1 / prevention & control*
Humans
Schistosoma / immunology*
T-Lymphocytes, Regulatory / immunology*