Ultrasonic-assisted fabrication and release kinetics of two model redox-responsive magnetic microcapsules for hydrophobic drug delivery

Abstract

The smart biocompatible carriers have an advantage in the high-efficiency delivery and stimuli-responsive release of drugs. This study describes two model magnetic microcapsules (MMC) fabricated by sonicating the hydrophobic drug-loaded oil phase in an albumin aqueous solution, where magnetic nanoparticles are either encapsulated into the core or embedded onto the albumin shell. The as-prepared MMC with magnetic shell (MS) or with magnetic core (MC) shows an appropriate dispersibility with a well-defined spherical morphology in water, an excellent magnetism-mediated shifting ability for targeted drug delivery, and a good biocompatibility for high-level cell viability. Moreover, both the two microcapsules also show a high efficiency to trap the hydrophobic drugs, where the embedding ratios are 87.41% for MMC-MS and 95.31% for MMC-MC, respectively. Meanwhile in current study, the release kinetics and mechanism reveal that the sulfhydryl-crosslinked shell structure endows the MMC with a redox-responsive behavior to release the contents for controlled drug release, and the release rate or the release amount can be adjusted by changing the dosage of reducing agent. Therefore, the MMC have great potential as a smart carrier of hydrophobic drugs for enhancing the therapeutic efficiency.

Keywords: Hydrophobic drug; Magnetic microcapsule; Redox-responsive; Release kinetics; Ultrasonic-assisted assembly.