Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology

Jerome A Dempsey; Curtis A Smith

doi:10.1016/j.ccm.2019.02.001

Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology

Clin Chest Med. 2019 Jun;40(2):269-283. doi: 10.1016/j.ccm.2019.02.001.

Authors

Jerome A Dempsey¹, Curtis A Smith²

Affiliations

¹ Department Population Health Sciences, University of Wisconsin-Madison, 707 WARF Building, 610 N. Walnut Street, WI 53726, USA. Electronic address: jdempsey@wisc.edu.
² Department Population Health Sciences, University of Wisconsin-Madison, 707 WARF Building, 610 N. Walnut Street, WI 53726, USA.

Abstract

We examine recent findings that have revealed interdependence of function within the chemoreceptor pathway regulating breathing and sympathetic vasomotor activity and the hypersensitization of these reflexes in chronic disease states. Recommendations are made as to how these states of hyperreflexia in chemoreceptors and muscle afferents might be modified in treating sleep apnea, drug-resistant hypertension, chronic heart failure-induced sympathoexcitation, and the exertional dyspnea of chronic obstructive pulmonary disease.

Keywords: Carotid-medullary chemoreceptor interdependence; Hypersensitization of chemoreception; Sensory hyperreflexia in chronic diseases.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cardiorespiratory Fitness / physiology*
Chemoreceptor Cells / physiology*
Humans
Sleep Apnea Syndromes / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding