β-Arrestin2 expressed in mast cells regulates ciprofloxacin-induced pseudoallergy and IgE-mediated anaphylaxis

Saptarshi Roy; Kshitij Gupta; Anirban Ganguly; Hydar Ali

doi:10.1016/j.jaci.2019.04.024

β-Arrestin2 expressed in mast cells regulates ciprofloxacin-induced pseudoallergy and IgE-mediated anaphylaxis

J Allergy Clin Immunol. 2019 Aug;144(2):603-606. doi: 10.1016/j.jaci.2019.04.024. Epub 2019 May 9.

Authors

Saptarshi Roy¹, Kshitij Gupta¹, Anirban Ganguly¹, Hydar Ali²

Affiliations

¹ Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa.
² Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa. Electronic address: alih@upenn.edu.

Abstract

The adapter protein β-arrestin2 inhibits Mrgprb2 and FcεRI-mediated mast cell degranulation to attenuate pseudo-allergy and anaphylaxis. Thus, targeting β-arrestin2 in mast cells could provide novel therapeutic options for modulating pseudo-allergy and anaphylaxis.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Anaphylaxis / chemically induced
Anaphylaxis / immunology*
Anaphylaxis / pathology
Animals
Ciprofloxacin / adverse effects*
Ciprofloxacin / pharmacology
Drug Hypersensitivity / immunology*
Drug Hypersensitivity / pathology
Gene Expression Regulation / drug effects
Gene Expression Regulation / immunology
Immunoglobulin E / immunology*
Mast Cells / immunology*
Mast Cells / pathology
Mice
Mice, Knockout
beta-Arrestin 2 / immunology*

Substances

Arrb2 protein, mouse
beta-Arrestin 2
Immunoglobulin E
Ciprofloxacin

Abstract

Publication types

MeSH terms

Substances

Grants and funding