Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers

Curr Top Med Chem. 2019;19(12):1051-1058. doi: 10.2174/1568026619666190510103416.

Abstract

Sirtuins family is a class of NDA+ dependent protein deacetylases that play a key role in the regulation of several aspects of biological processes, such as cell cycle regulation, autophagy, immune and inflammatory response. Many studies have shown that sirtuins2 as a key player in the cancer pathway is of great significance in tumorigenesis. This review summarizes the newly discovered, in recent years, some SIRT2 inhibitors for cancer target structure, action mechanism, biological activity, substrate specificity, and signaling pathways.

Keywords: Cancer; N-terminal; Signaling pathways; Sirt2 inhibitor; Sirtuins; Substrate..

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / therapeutic use
  • Drug Therapy, Combination
  • Epigenesis, Genetic / drug effects
  • Histone Deacetylase Inhibitors* / chemistry
  • Histone Deacetylase Inhibitors* / pharmacology
  • Histone Deacetylase Inhibitors* / therapeutic use
  • Humans
  • Molecular Docking Simulation
  • Neoplasms* / drug therapy
  • Neoplasms* / enzymology
  • Neoplasms* / genetics
  • Sirtuin 2 / antagonists & inhibitors*

Substances

  • Antineoplastic Agents
  • Histone Deacetylase Inhibitors
  • Sirtuin 2