Opioids for breathlessness: psychological and neural factors influencing response variability

Sara J Abdallah; Olivia K Faull; Vishvarani Wanigasekera; Sarah L Finnegan; Dennis Jensen; Kyle T S Pattinson

doi:10.1183/13993003.00275-2019

Opioids for breathlessness: psychological and neural factors influencing response variability

Eur Respir J. 2019 Sep 19;54(3):1900275. doi: 10.1183/13993003.00275-2019. Print 2019 Sep.

Authors

Sara J Abdallah^{1

2}, Olivia K Faull^{3

2}, Vishvarani Wanigasekera³, Sarah L Finnegan³, Dennis Jensen¹, Kyle T S Pattinson⁴

Affiliations

¹ Clinical Exercise & Respiratory Physiology Laboratory, Dept of Kinesiology & Physical Education, McGill University, Montréal, QC, Canada.
² Joint first authors.
³ Wellcome Centre for Integrative Neuroimaging and Nuffield Division of Anaesthetics, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁴ Wellcome Centre for Integrative Neuroimaging and Nuffield Division of Anaesthetics, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, UK kyle.pattinson@nda.ox.ac.uk.

Abstract

Diminished opioid efficacy in the treatment of breathlessness is related to negative affect and anticipatory brain activity in the anterior cingulate and medial prefrontal cortex. http://bit.ly/2LXyyDo

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Analgesics, Opioid
Cross-Over Studies
Dyspnea
Humans
Morphine*
Pulmonary Disease, Chronic Obstructive*

Substances

Analgesics, Opioid
Morphine

Grants and funding

G0802826/MRC_/Medical Research Council/United Kingdom