Hybrid organic-inorganic materials (HOIM), with high mechanical stability, large surface area, tailored pore size, controlled morphology, and organic loading have shown superior chiral separation performance. In this chapter, the preparation of hybrid organic-inorganic materials of core-shell silica microspheres by a layer-by-layer self-assembly method is described. The enantioseparation performance by high-performance liquid chromatography is illustrated by various types of chiral compounds under normal- and reversed-phase elution conditions. The chiral selector of nanocrystalline cellulose derivative hybrid organic-inorganic materials showed good performance in the separation of enantiomers.
Keywords: Chiral selectors; Enantioseparation; High-performance liquid chromatography; Hybrid organic-inorganic materials; Nanocellulose.