Abstract
Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-β-glucoside compound, is the main active ingredient of the Rhodiola root. Recently, various studies have suggested that Rhodiola and salidroside may have pharmacological properties that could be used in the treatment of diabetes, as studies have confirmed that AMP-activated protein kinase (AMPK) and AMPK-related signaling are connected with its beneficial effects. This review aims to summarize the research progress of Rhodiola and salidroside in the treatment of diabetes. A detailed summary of AMPK and AMPK-related signaling induced by Rhodiola and salidroside are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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AMP-Activated Protein Kinases / metabolism*
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Animals
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Biomarkers
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Clinical Studies as Topic
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Diabetes Mellitus / drug therapy
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Diabetes Mellitus / etiology
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Diabetes Mellitus / metabolism*
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Drug Evaluation, Preclinical
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Energy Metabolism / drug effects
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Enzyme Activation / drug effects
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Glucosides / chemistry
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Glucosides / pharmacology*
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Glucosides / therapeutic use
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Humans
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology*
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Hypoglycemic Agents / therapeutic use
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Molecular Targeted Therapy
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Oxidative Stress / drug effects
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Phenols / chemistry
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Phenols / pharmacology*
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Phenols / therapeutic use
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Rhodiola / chemistry*
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Signal Transduction / drug effects
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Structure-Activity Relationship
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Treatment Outcome
Substances
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Biomarkers
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Glucosides
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Hypoglycemic Agents
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Phenols
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Plant Extracts
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AMP-Activated Protein Kinases
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rhodioloside