Recent advances on fluorescent biomarkers of near-infrared quantum dots for in vitro and in vivo imaging

Shanmugavel Chinnathambi; Naoto Shirahata

doi:10.1080/14686996.2019.1590731

Recent advances on fluorescent biomarkers of near-infrared quantum dots for in vitro and in vivo imaging

Sci Technol Adv Mater. 2019 Apr 15;20(1):337-355. doi: 10.1080/14686996.2019.1590731. eCollection 2019.

Authors

Shanmugavel Chinnathambi¹, Naoto Shirahata^{2

3

4}

Affiliations

¹ International Center for Young Scientists, National Institute for Materials Science (NIMS), Tsukuba, Japan.
² International Center for Materials Nanoarchitectonics, NIMS, Tsukuba, Japan.
³ Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Japan.
⁴ Department of Physics, Chuo University, Tokyo, Japan.

Abstract

Luminescence probe has been broadly used for bio-imaging applications. Among them, near-infrared (NIR) quantum dots (QDs) are more attractive due to minimal tissue absorbance and larger penetration depth. Above said reasons allowed whole animal imaging without slice scan or dissection. This review describes in vitro and in vivo imaging of NIR QDs in the regions of 650-900 nm (NIR-I) and 1000-1450 nm (NIR-II). Also, we summarize the recent progress in bio-imaging and discuss the future trends of NIR QDs including group II-VI, IV-VI, I-VI, I-III-VI, III-V, and IV semiconductors.

Keywords: 204 Optics / Optical applications; 60 New topics / Others: Nanocrystals, Quantum dots, Bioimaging, Biomarkers, Fluorescence imaging; NIR imaging; Quantum dots; bio-marker; review.

Publication types

Review

Grants and funding

This work was supported by the Izumi Science and Technology Foundation [2018-J-053]; Japan Science and Technology Agency [AS282I006e].