Effector Specificity Mechanisms of Rab35 GTPase

Structure. 2019 May 7;27(5):725-727. doi: 10.1016/j.str.2019.04.011.

Abstract

The mechanism of GTPase specificity remains incompletely understood. In this issue of Structure, Lin et al. (2019) present crystal structures of Rab35 in complex with two effectors, ACAP2 and RUSC2, respectively, unraveling the molecular basis for the exquisite mutual specificity between Rab35 and these effectors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • ADP-Ribosylation Factors
  • GTPase-Activating Proteins*
  • rab GTP-Binding Proteins*

Substances

  • GTPase-Activating Proteins
  • ADP-Ribosylation Factors
  • rab GTP-Binding Proteins