Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas

Katharina Filipski; Yannick Braun; Jenny Zinke; Bastian Roller; Peter Baumgarten; Marlies Wagner; Christian Senft; Pia S Zeiner; Michael W Ronellenfitsch; Joachim P Steinbach; Karl H Plate; Gilles Gasparoni; Michel Mittelbronn; David Capper; Patrick N Harter

doi:10.1007/s00401-019-02025-9

Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas

Acta Neuropathol. 2019 Aug;138(2):331-334. doi: 10.1007/s00401-019-02025-9. Epub 2019 May 7.

Authors

Katharina Filipski^{1

2

3}, Yannick Braun¹, Jenny Zinke¹, Bastian Roller¹, Peter Baumgarten^{1

4}, Marlies Wagner⁵, Christian Senft⁴, Pia S Zeiner^{6

7}, Michael W Ronellenfitsch^{6

7

8}, Joachim P Steinbach^{6

7

8}, Karl H Plate^{1

2

3

8}, Gilles Gasparoni⁹, Michel Mittelbronn^{10

11

12

13}, David Capper^{14

15

16}, Patrick N Harter^{17

18

19

20}

Affiliations

¹ Institute of Neurology, (Edinger Institute), University Hospital, Frankfurt Am Main, Germany.
² German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Heidelberg, Germany.
³ German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Department of Neurosurgery, University Hospital, Frankfurt Am Main, Germany.
⁵ Institute of Neuroradiology, University Hospital, Frankfurt Am Main, Germany.
⁶ Department of Neurology, University Hospital, Frankfurt Am Main, Germany.
⁷ Dr. Senckenberg Institute of Neurooncology, University Hospital, Frankfurt Am Main, Germany.
⁸ Frankfurt Cancer Institute (FCI), Frankfurt Am Main, Germany.
⁹ Department of Genetics, University of Saarland, Campus A2 4, Saarbrücken, Germany.
¹⁰ Luxembourg Centre of Neuropathology (LCNP), Luxembourg City, Luxembourg.
¹¹ Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg City, Luxembourg.
¹² Laboratoire National de Santé (LNS), Dudelange, Luxembourg.
¹³ NORLUX Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.
¹⁴ Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
¹⁵ Department of Neuropathology, Berlin Institute of Health, Berlin, Germany.
¹⁶ German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁷ Institute of Neurology, (Edinger Institute), University Hospital, Frankfurt Am Main, Germany. patrick.harter@kgu.de.
¹⁸ German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Heidelberg, Germany. patrick.harter@kgu.de.
¹⁹ German Cancer Research Center (DKFZ), Heidelberg, Germany. patrick.harter@kgu.de.
²⁰ Frankfurt Cancer Institute (FCI), Frankfurt Am Main, Germany. patrick.harter@kgu.de.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms / genetics*
Brain Neoplasms / mortality
Brain Neoplasms / pathology
Chromosome Deletion*
Chromosomes, Human, Pair 1 / genetics*
Chromosomes, Human, Pair 1 / ultrastructure
Chromosomes, Human, Pair 19 / genetics*
Chromosomes, Human, Pair 19 / ultrastructure
DNA Methylation
DNA, Neoplasm / genetics
Glioma / genetics*
Glioma / mortality
Glioma / pathology
Histone Code*
Histones / metabolism*
Humans
Isocitrate Dehydrogenase / genetics
Kaplan-Meier Estimate
Neoplasm Proteins / genetics
Prognosis

Substances

DNA, Neoplasm
Histones
Neoplasm Proteins
Isocitrate Dehydrogenase